So, when de-prescribing is implemented, it is significant and it may impact about 17%, 20% of patients, and there were some Canadian studies done 1 by-I believe Marissa Battistella and colleagues-where they were able to show that after de-prescribing a certain number of target medications, that patients remained off of those medications, 50% of them remained off medications at 6 months. Some other challenges include time constraints, whose role is it, defining roles amongst the different providers and taking the responsibility. Some of the issues that have come up are really interconnectability between different electronic health records, and that really is problematic because if the electronic health record in the dialysis unit is different from the health record for the patient-in the health system in which they received their other care-then 1 of the biggest interventions is medication reconciliation. Peter, and other colleagues looked at what are some of the qualitative factors that impact de-prescribing in patients on dialysis. So, it's actually been an area of interest in multiple studies now. Linda Awdishu: Yeah, that's a really excellent question. Pharmacy Times: What are some key challenges and considerations when prescribing and de-prescribing medications for patients with advanced chronic kidney disease (CKD)?
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